This pharmacodynamic hypothesis suggests a considerable inoculum effect, which we quantified. The measured growth curves, together with single-cell observations and peptide depletion assays, suggested that addition of a sub- MIC concentration of pexiganan to a population of this bacterium killed a fraction of the cells, reducing peptide activity during the process, while leaving the remaining cells unaffected.
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coli, using a plate reader and manual plating (i.e. These results led to a detailed study of the effect of pexiganan on the growth curve of E.
We measured the minimum inhibitory concentration ( MIC) of the antimicrobial peptide pexiganan acting on Escherichia coli, and found an intrinsic variability in such measurements. Jepson, Alys K Schwarz-Linek, Jana Ryan, Lloyd Ryadnov, Maxim G Poon, Wilson C K What Is the 'Minimum Inhibitory Concentration' ( MIC) of Pexiganan Acting on Escherichia coli?-A Cautionary Case Study.
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